BRIdGE implements a Bayesian approach for identifying gene-environment interactions when paired phenotypic measurements are taken under two environmental conditions. This method explicitly considers specific interaction models, while taking into account both sample pairing and the intra-individual correlation of measurements under the two conditions. Details are given in the following publication:

Maranville JC, Luca F, Richards AL, Wen X, Witonsky DB, Baxter S, Stephens M, Di Rienzo A. Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response. PLoS Genetics. (In press.)

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